Breast Cancer Month Happenings

ONGOING

Shop Pink and Save, through October, St. Augustine Outlets, Interstate 95 and Florida 16, St. Augustine. Discount cards available at Guest Services for $2. Receive up to 30 percent off a purchase or item to benefit area charities that support breast cancer research, support and treatment, including the Susan G. Komen Foundation, The Donna Foundation, Bosom Buddies and Pink Up the Pace. Free Women’s Health Fair, focusing on all aspects of healthy living on Saturday, with information on breast health, diabetes, nutrition and more. (904) 826-1052 or staugoutlets.com.

Pink Sisters and Friends Advocacy support for breast cancer survivors. Pink sisters go through the regular on-boarding process, education, testing and training related to breast cancer, then are matched with a patient (pinkie) whose diagnosis and treatment is similar. Hotline, (904) 953-6316.

Survival Strap breast cancer ribbons and 26.2 Donna bracelets, with 25 percent of proceeds to benefit The Donna Foundation. survivalstrapsusa.wordpress.com.

 

FRIDAY

Upbeat Pink: A Musical Tribute to Breast Cancer Survivorship themed “An Evening with James Bond and Friends,” 7:30 p.m., University of North Florida’s Lazzara Performance Hall. Features the UNF Wind Symphony and guest ensembles. Free. (904) 953-0707 or facebook.com/breastclinic.

 

SATURDAY

Making Strides Against Breast Cancer of Jacksonville 5K Walk, 9 a.m., Best Bet, 455 Park Ave., Orange Park. Wear a pink bra (optional). (904) 284-2661 or facebook.com/makingstridesagainstbreastcanceroforangepark.

Shop Pink Women’s Health Fair, 11 a.m.-4 p.m., St. Augustine Outlets, Interstate 95, Exit 218, east side of interstate. Features information on healthy living, demonstrations, giveaways, health screenings, Chase the Pink Heals fire truck and a gift bag. Includes Bobbi Hanks, founder of Bosom Buddies, at 1 p.m. and Managing Diabetes at 2 p.m. (904) 826-1052 or staugoutlets.com.

VIPink Bridal Experience to benefit Brides Against Breast Cancer, 1-5 p.m., CoWork Jax, 5 W. Forsyth St. Includes a silent auction. $10 in advance, $15 at the door; $20 VIP, includes a gift bag with coupons and gift certificates; $25 Platinum, includes a swag bag filled with goodies. Print ticket and bring to event. vipinkbridalexperience.eventbrite.com.

Breast Cancer Awareness Tea Party: A Cup of Inspiration, 1-5 p.m., Hyatt Regency Hotel, 225 E. Coast Line Drive. Includes Angela Robinson of the Tyler Perry Show, singer Akia Uwanda and comedian Terry Harris. $30. (904) 469-4136.

Get hair and nails done to benefit Susan G. Komen for the Cure, 2-5 p.m., Victoria’s Hair and Nails, 2485 Monument Road. $10, haircuts, manicures and paraffin services. Includes entertainment by Party Solutions, representatives on hand to register participants for the Oct. 19 Race for the Cure at Metro Park, raffle prizes and refreshments. (904) 642-0488 or komennorthflorida.org.

Anniversary celebration to benefit The Donna Foundation, 5-7 p.m., Royal Palm Village Wine and Tapas, 296 Royal Palms Drive, Atlantic Beach. Second-year anniversary celebration with a grand wine tasting and luau-style roasting. $30 a person, includes an etched wine glass. (904) 372-0052 or royalpalmwines.com.

Victory in Pink, a celebration of women who have fought breast cancer, 6-9 p.m., St. Johns Town Center, 4663 River City Drive. Includes free food, free samples, makeovers, the mobile mammography unit — call (904) 308-5490 for an appointment, a Breast Cancer Survivor Show and Education, face painting for the kids and live entertainment with The Gootch. (904) 308-7300 or jaxhealth.com.

 

SUNDAY

Cut-a-Thon to benefit Breast Cancer Research Foundation, 11 a.m.-4 p.m., Daniel James Salon, 45 W. Bay St. In addition, offering waxes, styles and haircuts. (904) 359-2006.

 

MONDAY

Mobile Mammogram Unit as a kickoff to Community Days, 1-3 p.m.; volunteers package Comfort Kits, 9 a.m.-5 p.m. Tuesday-Thursday, 4345 Southpoint Blvd. Comfort Kits care packages contain essentials that help provide comfort and relief to men, women and children undergoing chemotherapy treatment. givingcomfort.org.

Pink Ribbon Ladies breast cancer support group in Nassau County, 6-7:30 p.m., Baptist Medical Center Nassau, Conference Room. (904) 321-2057 or 261-2976.

Pink Ribbon Golf Classic, Underwood Jewelers Trunk Show and Cocktail Party, 6-8 p.m., Underwood Jewelers, 330 Florida A1A N., Ponte Vedra Beach, with a raffle drawing (tickets $20) and check presentations to Baptist Medical Center Beaches and Mayo Clinic-Jacksonville. Registration, pinkribbonjax.org.

Bosom Buddies, support and education program for breast cancer survivors and women at high risk, 7-8:30 p.m. Mondays, Women’s Center of Jacksonville, 5644 Colcord Ave. (904) 722-3000, ext. 224.

 

TUESDAY

Candid Conversations about Breast Cancer, educational support group for breast cancer survivors and their caregivers, 6-7 p.m., St. Vincent’s Mary Virginia Terry Cancer Center, 2 Shircliff Way, second floor. Park free on second floor of the DePaul Building parking garage. (904) 308-5490.

 

WEDNESDAY

Interchanges Pink Out to benefit North Florida Susan G. Komen for the Cure, 5:30-8:30 p.m., River City Brewing Company, 835 Museum Circle. Includes a raffle giveaway. Wear pink. (904) 834-4662 or 398-2299.

SenioRITAs Tennis Tournament to benefit The Rita Foundation. (904) 806-3613 or the-rita-foundation.org/senioritas.

■ Auction and Cocktail Party, 6 p.m. Wednesday, Sawgrass Country Club. Includes light cuisine and a cash bar. $40, included in player registration fee.

■ Women’s Doubles Tennis Tournament for women 40 and older, 8 a.m. Oct. 18-20, Sawgrass Country Club. $85, includes auction and party.

 

THURSDAY

Your Financial Future, Now! Seminar, presented by MassMutual, 6-7:30 p.m., Julington Creek Plantation Recration Center’s Cypress Room, 350 Plantation Club Parkway, St. Johns. Includes a Vera Bradley bag giveaway and refreshments. Mass/Mutual will donate $1,000 to The Donna Foundation. Reserve by Tuesday. (904) 599-2588 or 997-2325.

 

OCT. 19

Touchdown Against Cancer Games, 8 a.m., Bob Hayes Sports Complex, 5054 Soutel Drive. Breast cancer survivors who are ex-flag football players will be honored. Includes several flag football games. Donations being accepted for the Sister/Hermane Foundation, beginning in 2014. (904) 765-4321.

Race for the Cure to benefit Susan G. Komen for the Cure, late registration, 6:30 a.m.; 5K race, 9 a.m.; 2K run/walk, 9:45 a.m.; awards, 10:30 a.m.; Metropolitan Park, across from EverBank Field. komennorthflorida.org.

 

OCT. 21

Bosom Buddies, support and education program for breast cancer survivors and women at high risk, 7-8:30 p.m. Mondays, Women’s Center of Jacksonville, 5644 Colcord Ave. (904) 722-3000, ext. 224.

Young Survivors Group, presented by the Bosom Buddies program, 7-8:30 p.m., Women’s Center of Jacksonville, 5644 Colcord Ave. Registration, (904) 722-3000, ext. 224.

Wrap Up Halloween Party to benefit Making Strides Against Breast Cancer, Best Bet, 455 Park Ave., Orange Park. (904) 284-2661 or facebook.com/makingstridesagainstbreastcanceroforangepark.

 

OCT. 26

5K Walk/Run to benefit Making Strides Against Breast Cancer of Jacksonville, 9 a.m., The Jacksonville Landing. Wear a pink bra (optional). (904) 285-4225, makingstrideswalk.org or facebook.com/makingstridesjax.

Run for the Tata’s to benefit the American Cancer Society, kickstands up at noon, Lakeshore Bar, 2420 Lakeshore Blvd. $15 a bike, $5 passenger. Includes a meal at the end of the run. (904) 389-9224.

 

OCT. 28

Bosom Buddies, support and education program for breast cancer survivors and women at high risk, 7-8:30 p.m. Mondays, Women’s Center of Jacksonville, 5644 Colcord Ave. (904) 722-3000, ext. 224.

 

UPCOMING

Bike 26.2 with Donna, check-in, 6:30 a.m. Nov. 10, Bartram Trail High School, 7399 Longleaf Pine Parkway, St. Johns. Includes a 110-mile ride, 7:45 a.m.; 52.4-mile ride, 8 a.m.; 26.2-mile ride, 8:15 a.m.; and 13.1-mile ride, 8:30 a.m.; postrace celebration with free lunch for registered participants, 10 a.m.-4 p.m. Register online by Nov. 4. breastcancermarathon.com.

 

Fax to (904) 359-4478 or email events@jacksonville.com. Complete listing at jacksonville.com/calendars. To put your event in the free online calendar, go to events.jacksonville.com.

Source: http://jacksonville.com/news/health-and-fitness/2013-10-10/story/breast-cancer-month-happenings
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For those who leave the Hasidic world, new life starts slowly

By Alissa Figueroa
Rock Center

In the heart of New York City, a deeply religious community has created its own secluded island, where Yiddish is the primary language, men wear towering black hats and long robes even on the most sweltering summer day, and mothers lead broods of eight or 10 children.

They are Hasidic Jews - the descendants of a small group of ardent followers whose Eastern European villages were all but decimated during the Holocaust. For the better part of the last century they've been building their own communities in Brooklyn, maintaining the dress, language and traditions of their ancestors.

There?s an estimated 300,000 people living in various Hasidic communities in New York City, and they're poised to become the largest Jewish denomination in the city in the next two decades.

"There's a conviction that their way of life is special, unique, authentic," says Samuel Heilman, professor of Anthropology at Queens College. "It's a belief that what comes from the past is superior to what is in the present."

Much of the secular world is off-limits, including television, non-religious books and most websites.

Instead, religious study is emphasized, as is devotion to God and family. Most Hasids are wedded in arranged marriages while in their teens or early 20s. In a few years, they?re expected to be on their way to building a large family.

Avraham Berkowitz is a rabbi in the Lubavitcher Hasidic community. He says that this focus on family and religion is worth preserving.

?The modesty in the dress, the language in the house, standing up for parents, not interrupting when adults are speaking. That kind of protected lifestyle, that is what we have today,? says Berkowitz.

?You have to be able to pick and choose what to bring in and what to keep out that's negative.?

LEAVING THE COMMUNITY

But that seemingly simple life, while comforting and fulfilling for some, can feel oppressive for others.

?Most of the individuals that are coming to us, what we're seeing is they just want to learn. They want to study physics.? And they want to study how atoms work.? And they want to study math.? says Lani Santo, executive director of Footsteps, the only organization in New York that helps people leave Hasidic communities.

Sam Katz is a Footsteps member. A yearning for knowledge drew him away from the Hasidic neighborhood in Brooklyn where he was raised and into Manhattan. He describes sneaking into the Museum of Natural History, where the dinosaur skeletons caught his imagination like nothing in his religious books.

?There was something so connected about standing next to a dinosaur, something so-- universally harmonious-- for lack of a better word,? says Katz. ?It was just a feeling of this fantasy world.?

Katz?s secular education stopped when he reached middle school, when he, like other Hasidic boys, began focusing exclusively on religious study.?Yet, he?s managed to earn a bachelor?s degree in biochemistry, and is headed to Berlin in the fall on a Fulbright scholarship.

Hindy Sabel, who also left her Hasidic upbringing with the help of Footsteps, says she started questioning the Hasidic way of life as a child. She wanted to ride bikes around the neighborhood, says Sabel, like the boys could. And she wasn?t ready to get married before finishing college.

?I couldn?t be a leader in that community and I wanted to do something with my life,? says Sabel. That?s when she came to Footsteps with an older sister. Today, she?s working full time and studying for an MBA at New York University.

But picking up and leaving behind everything they?ve ever known isn?t easy. The process can take years of catching up.

?Footsteps members are very much like immigrants,? explains Santo. ?But they're immigrants to a country that they're citizens in.?

CONFRONTING PROBLEMS WITHIN

For Judy Braun, 31, getting out was particularly difficult.

Braun grew up strictly Hasidic in Borough Park, Brooklyn, and recalls a happy childhood filled with summer camping trips in the Catskills.

But when she was 12, Braun says she had a terrifying experience that would haunt her the rest of her life ? she found her friend trying to hang herself in the bathroom, and learned she?d been sexually abused.

Braun says the adults she told about the attempted suicide turned a deaf ear. She says she saw firsthand how the community refused to acknowledge that one of its own could abuse a child.

?Our rules and our laws will keep us pure, will keep these things from happening. Coming to terms with the fact that they will happen regardless undermines the entire idea of the truth,? says Braun. ?If our way of life doesn't prevent our men from turning into beasts, then what's the point of our way of life??

---

Feeling trapped by tradition, Braun ultimately got married and had children.? But in her mid-twenties, she started secretly writing about what she saw as a child.

That fictionalized account of her ordeal, "Hush," was published anonymously in 2010. While some supported her efforts, when her real name leaked out as the author, she said threats started coming in.? She received a copy of her book covered in fake blood, her car windows were smashed, and threatening messages were left on her phone.

?When you're an author of a book and you publicly shame the community, there is a full-out campaign against you at every level,? says Braun.

Rabbi Avraham Berkowitz says people are now acknowledging sexual abuse is happening.

?These type of crimes have to be eradicated,? He says. He insists, though, that the community can handle the problem internally.? ?We have to do it within the way the community knows how to solve its problems.? Cause sometimes when you come banging with drums from the outside, the community becomes more insular.?

In the last two years, Braun has come out publicly as the author of "Hush"? and started speaking out against abuse in the community. She recently divorced her husband and moved her children outside the boundaries of her old Hasidic neighborhood.

?It gives you more psychological safety,? says Braun. ?Even though it's not that far a drive, but you?re in a different place.?

?

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2da1685b/l/0Lrockcenter0Bnbcnews0N0C0Inews0C20A130C0A60C210C190A80A2780Efor0Ethose0Ewho0Eleave0Ethe0Ehasidic0Eworld0Enew0Elife0Estarts0Eslowly0Dlite/story01.htm

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Wing walker, pilot die in crash at Ohio air show

CINCINNATI (AP) ? The plane that crashed at an Ohio air show, killing the pilot and stunt walker, is registered to a veteran wing walker.

Federal records show that the Boeing Stearman biplane that crashed Saturday at the Vectren Air Show near Dayton was registered to Jane Wicker of Loudon, Va.

The Federal Aviation Administration says Wicker was also a contract employee who worked as an FAA budget analyst.

An FAA official says the kind of aircraft that crashed was heavily used for pilot training during World War II.

The plane turned upside-down as Wicker sat on top of the wing before it titled and crashed into the ground, bursting into flames.

The air show canceled the rest of Saturday's events after the crash but planned to resume Sunday.

Source: http://news.yahoo.com/wing-walker-pilot-die-crash-ohio-air-show-191655523.html

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Looking for a home on land within commuting ... - Zillow Real Estate ...

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Source: http://www.zillow.com/advice-thread/Looking-for-a-home-on-land-within-commuting-distance/498405/

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Changes in cell shape may lead to metastasis, not the other way around

June 21, 2013 ? A crucial step toward skin cancer may be changes in the genes that control cell shape, report a team of scientists from The Methodist Hospital Research Institute, the Institute of Cancer Research, London, and Harvard Medical School in an upcoming issue of Nature Cell Biology (now online).

Using automated high content screening and sophisticated computational modeling, the researchers' screening and analysis of tens of millions of genetically manipulated cells helped them identify more than a dozen genes that influence cell shape. Their work could lead to a better understanding of how cells become metastatic and, eventually, pinpoint new gene therapy targets for cancer treatment.

"We found that by altering the way the cells are grown to better mimic conditions in a living organism, gene expression could have a profound impact on cell shape," said Zheng Yin, the paper's lead author and a postdoctoral fellow at the Department of Systems Medicine and Bioengineering of The Methodist Hospital Research Institute (TMHRI). "This matters because many cancer biologists believe metastasis depends in part on the ability of cells to take on different shapes to escape their confines and spread to healthy tissue. We developed a method of identifying and analyzing the shapes of fruit fly cells, then validated and expanded the discoveries in mammal cancer cells.."

The scientists began their study in fruit fly immune cells called hemocytes. Under normal conditions, each hemocyte was found to take on just one of five distinct shapes about 98 percent of the time. In contrast to conventional wisdom, other shapes and "intermediate" forms were rare, suggesting genes that control cell shape behave more like light switches than teakettles coming to a slow boil. Genetic manipulation of these cells in a lab setting supported that view as well.

Next the group examined human and mouse melanoma cells, which also take on a variety of forms. The researchers identified seven genes that cause cells to take on an especially rounded form, or else an elongated form. One of these genes, PTEN, had a particularly strong impact. When turned off, virtually all cells became elongated or large and rounded, two shapes that can help cancerous cells escape confinement, travel blood vessels, and infiltrate healthy tissues. This information about PTEN is new, even though the gene was previously known to scientists as a tumor suppressor.

"By increasing the frequency of rounded and elongated cells this would provide metastatic cells with a survival advantage that is otherwise not gained by adopting only a single shape, or being highly plastic," said TMHRI Department of Systems Medicine and Bioengineering Chair Stephen T.C. Wong, Ph.D., P.E., who with Institute of Cancer Research, London, Fellow Chris Bakal, Ph.D., are the corresponding authors who oversaw the research.

Bakal added, "The cells have to become rounded to travel through the bloodstream or invade soft tissues such as the brain, but they take on an elongated shape to travel through harder tissues like bone. But until now, we knew hardly anything about how the cells assume either of these shapes and how they switch between the two."

Yin said he hopes data from the study will be useful to cell and developmental biologists who are interested in how and why many different kinds of animal cells change their shapes.

"I believe this dataset has great potential," he said. "We still saw three distinct shapes other than rounded and elongated, and a handful of cell populations enriched with intermediate shapes -- a lot of possibilities for hypothesis generation."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/MZnLMdSRuDo/130621141658.htm

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Dakar Fashion Week targets city's working class

DAKAR, Senegal (AP) ? Organizers of Dakar Fashion Week have staged a show in a working-class suburb as part of a bid to democratize high fashion.

The show on Friday night attracted thousands of residents, who offered vocal, real-time assessments of the clothes on display while cheering loudly for the more famous models.

Organizer Adama Ndiaye, who launched Dakar Fashion Week 11 years ago, said she hoped the project would further her dream of making high fashion as accessible to the working-class as it is for the wealthy.

The show was part of a six-day event featuring 18 designers, seven from Senegal and others from as far away as Germany and Brazil. Shows were scheduled to be held in three different locations throughout Dakar.

Source: http://news.yahoo.com/dakar-fashion-week-targets-citys-working-class-145325716.html

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LeBron James Leads Heat To NBA Finals Game 7 Win Over Spurs, 2nd Straight Title (VIDEO/PHOTOS)

MIAMI -- Victory in Game 7 brought more than another crown for LeBron James and the Miami Heat. It validated the team and its leader, forever cementing their place among the NBA's greats.

For the vanquished San Antonio Spurs, it simply compounded the misery of a championship that got away.

James led the Heat to their second straight title, scoring 37 points and grabbing 12 rebounds in a 95-88 victory Thursday night in a tense game that was tight until Miami pulled away in the final minute.

Capping their best season in franchise history ? and perhaps the three-superstar system they used to build it ? the Heat ran off with the second straight thriller in the NBA's first championship series to go the distance since 2010.

Two nights after his Game 6 save when the Heat were almost eliminated, James continued his unparalleled run through the basketball world, with two titles and an Olympic gold medal in the last 12 months.

"I work on my game a lot throughout the offseason," said James, who was MVP for the second straight finals. "I put a lot of work into it and to be able to come out here and (have) the results happen out on the floor is the ultimate. The ultimate. I'm at a loss for words."

He made five 3-pointers, defended Tony Parker when he had to, and did everything else that could ever be expected from the best player in the game.

The Heat became the NBA's first repeat champions since the Lakers in 2009-10, and the first team to beat the Spurs in the NBA Finals.

"It took everything we had as a team," Dwyane Wade said. "Credit to the San Antonio Spurs, they're an unbelievable team, an unbelievable franchise. This is the hardest series we ever had to play. But we're a resilient team and we did whatever it took."

Players and coaches hugged afterward ? their respect for each other was obvious from the opening tipoff of Game 1 through the final buzzer.

A whisker away from a fifth title two nights earlier, the Spurs couldn't find a way to win it all in what was perhaps the last shot for Tim Duncan, Parker and Manu Ginobili to grab another ring together.

"In my case I still have Game 6 in my head," Ginobili said. "Today we played an OK game, they just made more shots than us. LeBron got hot. Shane (Battier), too. Those things can happen. But being so close and feeling that you are about to grab that trophy, and seeing it vanish is very hard."

They were trying to become the first team to win a Game 7 on the road since Washington beat Seattle in 1978, but those old guys ran out of gas just before the finish.

Fans stood, clapped and danced as the clock ticked down, when every score was answered by another score, each stop followed by a better stop. The Heat pushed their lead to six points a few times midway through the fourth but San Antonio kept coming back.

Duncan had 24 points and 12 rebounds for the Spurs, but missed a shot and follow attempt right under the basket with about 50 seconds left and the Spurs trailing by two.

James followed with a jumper ? the shot the Spurs were daring him to take earlier in the series ? to make it 92-88, sending San Antonio to a timeout as Glenn Frey's "The Heat Is On" blared over the arena's sound system.

He then came up with a steal and made two free throws for a six-point lead, and after Ginobili missed, James stalked toward the sideline, knowing it was over and that he was, once again, the last one standing.

Wade had 23 points and 10 rebounds for the Heat, who overcame a scoreless Chris Bosh by getting six 3-pointers and 18 points from Shane Battier.

"It was a great series and we all felt that," Spurs coach Gregg Popovich said. "I don't know if `enjoy' is the right word, but in all honesty, even in defeat, I'm starting to enjoy what our group accomplished already, when you look back. And you need to do that, to put in perspective. So it's no fun to lose, but we lost to a better team. And you can live with that as long as you've given your best, and I think we have."

Streamers fell from the arena ceiling onto the fans for the second year in a row, but this one meant so much more. A narrow escape in Game 6 was still fresh in everyone's mind.

They were down 10 in the fourth quarter of that one before James led the charge back, finishing with a triple-double in Miami's 103-100 overtime victory. This one was nearly as tight, neither team leading by more than seven and the game tied 11 times.

Kawhi Leonard had 19 points and 16 rebounds for the Spurs, who had been 4 for 4 in the championship round. Ginobili had 18 points but Parker managed just 10 points on 3-of-12 shooting.

"Just give credit to the Miami Heat. LeBron was unbelievable. Dwyane was great. I just think they found a way to get it done," Duncan said. "We stayed in the game. We gave ourselves opportunities to win the game, we just couldn't turn that corner."

The Heat and coach Erik Spoelstra collected the Larry O'Brien trophy again from Commissioner David Stern, presiding over his final NBA Finals before retiring next February.

He couldn't have asked for a better way to go out.

James avenged his first finals loss, when his Cleveland Cavaliers were swept by the Spurs on 2007. That helped send James on his way to South Florida, realizing it would take more help to win titles that could never come alone.

He said he would appreciate this one more because of how tough it was. The Heat overpowered Oklahoma City in five games last year, a team of 20-something kids who weren't ready to be champions yet.

This came against a respected group of Spurs whose trio has combined for more than 100 playoff victories together and wanted one more in case this was San Antonio's last rodeo.

Duncan is 37 and Ginobili will be a 36-year-old free agent next month, the core of a franchise whose best days may be behind them.

Meanwhile, it's a potential dynasty along Biscayne Bay, but also one with a potentially small window. Wade's latest knee problems are a reminder that though he came into the NBA at the same time as James and Bosh, he's a couple of years older at 31 with wheels that have seen some miles.

James can become a free agent again next summer with another decision ? though hopefully not another Decision ? to make. He's comfortable in Miami and close with Wade, and the Heat have the leadership and commitment from owner Micky Arison and president Pat Riley to keep building a championship core around him.

Why would he want to leave?

San Antonio's most recent title came at James' expense. The Spurs exploited the weaknesses in James' game though knew someday they would be gone, Duncan telling him afterward that the league would someday belong to James.

And James simply isn't giving it back.

He came in averaging 33.8 points in Game 7s, already the best in NBA history, and was even better in this one.

He can't be defended the way he was six years ago, too strong inside and too solid from the outside. He drove Danny Green back like a tackling dummy to convert a three-point play in the second quarter, then knocked down a 3-pointer for the Heat's next score.

Heat fans, criticized over the last two days after many bolted before the finish Tuesday and then tried to force their way back in, weren't going anywhere early in this one. The game was too good.

And there was another celebration to watch.

The Heat had the classic championship hangover through the first few months of this season, too strong to lose at home but not committed enough to win on the road, where they were just 11-11 following a 102-89 loss in Indiana on Feb. 1.

They won in Toronto two nights later on Super Bowl Sunday and didn't lose again until well into March Madness, running off 27 straight victories before falling in Chicago on March 27 and finishing a franchise-best 66-16.

The small-market Spurs have always been a ratings killer, but interest grew throughout this series in their attempt to toppled the champs. Game 6 drew more than 20 million viewers, a total that Game 7 was expected to top.

And the games got better, too. Games 2-5 were all decided by double digits, neither team able to carry its momentum from one game to the next.

This one was back and forth for more than three quarters, with Mario Chalmers' 3-pointer at the buzzer giving Miami a 72-71 lead heading to the final 12 minutes of the season.

Game 6 could have shaken the Spurs, who were so close to holding the trophy that officials were preparing the championship presentation before Miami's rally. The Spurs held a team dinner late that night, figuring the company was better than having to dwell on the defeat alone in their rooms.

The pain of that game or the pressure of this one had little effect on their veterans but brought out a change in their leader, the subject of some rare second-guessing for his rotations near the end of the collapse.

The famously blunt Popovich was in a chatty mood pregame, actually preferring to stay and talk even when there were no more questions, saying the busier he was, the less he'd worry.

"It's torture," he said earlier of Game 7s. "It's hard to appreciate or enjoy torture."

But it sure was beautiful to watch.

The sport's most pressure-packed game had a nervous start, each team making just seven baskets in the first quarter and combining for seven turnovers. The Spurs took an early seven-point lead, but a pair of 3-pointers by Battier during an 8-0 run helped Miami take an 18-16 lead.

The Heat nursed a narrow lead for most of the second quarter, and after San Antonio went ahead in the final minute of the period, James tipped in a miss before Wade knocked down a jumper with 0.8 seconds left to send the Heat to the locker room with a 46-44 edge.

Notes: Home teams are 15-3 in Game 7s of the NBA Finals. ... Miami improved to 5-3 all-time in Game 7s in the postseason and became the fourth team to win the final two games at home since the finals went to a 2-3-2 format in 1985, joining the Lakers in 1988 and 2010, and Houston Rockets in 1994. ... Green was just 1 for 12, going 1 for 6 behind the arc. He started the series by making 25 3s in the first five games, a finals record for an entire series.

___

Follow Brian Mahoney on Twitter: http://www.twitter.com/Briancmahoney

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Source: http://www.huffingtonpost.com/2013/06/21/lebron-james-heat-nba-finals-game-7_n_3476078.html

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WSJ: The FAA Is Ready to Ease Restrictions on In-Flight Electronics

The Wall Street Journal is reporting that the Federal Aviation Administration is about to loosen its restrictions on in-flight gadget use?more than a year after it first announced it was mulling the idea.

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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/sHa3330zWAc/wsj-the-faa-is-ready-to-ease-restrictions-on-in-flight-528724592

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ESPN Lost Signal As Bill Simmons Mentions 'The Decision' After Heat Win Title, Conspicuously (VIDEO)

Dwyane Wade , Gabrielle Union

The Miami Heat's Dwyane Wade celebrated with his girlfriend Gabrielle Union after Game 7 of the NBA basketball championship against the San Antonio Spurs, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Wilfredo Lee)

San Antonio Spurs v Miami Heat - Game 7

MIAMI, FL - JUNE 20: Chris Andersen #11 of the Miami Heat celebrates after defeating the San Antonio Spurs 95-88 to win Game Seven of the 2013 NBA Finals at AmericanAirlines Arena on June 20, 2013 in Miami, Florida. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, User is consenting to the terms and conditions of the Getty Images License Agreement. (Photo by Kevin C. Cox/Getty Images)

LeBron James

The Miami Heat's LeBron James (6) celebrates in the locker room after Game 7 of the NBA basketball championship against the San Antonio Spurs, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Wilfredo Lee)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

Dwyane Wade of the Miami Heat enjoys a cigar in the team locker room after Game 7 of the NBA Finals at the American Airlines Arena June 20, 2013 in Miami, Florida. The Miami Heat beat the San Antonio Spurs 95-88 to win the 2013 NBA Championship. AFP PHOTO / Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

The Miami Heat's Ray Allen celebrates after Game 7 of the NBA basketball championship against the San Antonio Spurs, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Wilfredo Lee)

San Antonio Spurs v Miami Heat - Game 7

MIAMI, FL - JUNE 20: Mario Chalmers #15 of the Miami Heat celebrates as he answers questions after defeating the San Antonio Spurs 95-88 to win Game Seven of the 2013 NBA Finals at AmericanAirlines Arena on June 20, 2013 in Miami, Florida. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, User is consenting to the terms and conditions of the Getty Images License Agreement. (Photo by Kevin C. Cox/Getty Images)

San Antonio Spurs v Miami Heat - Game 7

MIAMI, FL - JUNE 20: LeBron James #6 of the Miami Heat celebrates with Carolina Panthers quarterback Cam Newton after defeating the San Antonio Spurs 95-88 to win Game Seven of the 2013 NBA Finals at AmericanAirlines Arena on June 20, 2013 in Miami, Florida. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, User is consenting to the terms and conditions of the Getty Images License Agreement. (Photo by Kevin C. Cox/Getty Images)

San Antonio Spurs v Miami Heat - Game 7

MIAMI, FL - JUNE 20: LeBron James #6 of the Miami Heat celebrates with fans after defeating the San Antonio Spurs 95-88 to win Game Seven of the 2013 NBA Finals at AmericanAirlines Arena on June 20, 2013 in Miami, Florida. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, User is consenting to the terms and conditions of the Getty Images License Agreement. (Photo by Kevin C. Cox/Getty Images)

San Antonio Spurs v Miami Heat - Game 7

MIAMI, FL - JUNE 20: LeBron James #6 of the Miami Heat celebrates after defeating the San Antonio Spurs 95-88 to win Game Seven of the 2013 NBA Finals at AmericanAirlines Arena on June 20, 2013 in Miami, Florida. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, User is consenting to the terms and conditions of the Getty Images License Agreement. (Photo by Kevin C. Cox/Getty Images)

San Antonio Spurs v Miami Heat - Game 7

MIAMI, FL - JUNE 20: LeBron James #6 of the Miami Heat celebrates with fans after defeating the San Antonio Spurs 95-88 to win Game Seven of the 2013 NBA Finals at AmericanAirlines Arena on June 20, 2013 in Miami, Florida. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, User is consenting to the terms and conditions of the Getty Images License Agreement. (Photo by Kevin C. Cox/Getty Images)

LeBron James

The Miami Heat's LeBron James (6) celebrates in the locker room after Game 7 of the NBA basketball championship against the San Antonio Spurs, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Wilfredo Lee)

Chris Andersen

Miami Heat's Chris Andersen reacts after Game 7 of the NBA basketball championships, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Wilfredo Lee)

LeBron James

Miami Heat's LeBron James reacts after Game 7 of the NBA basketball championships, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Wilfredo Lee)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

LeBron James of the Miami Heat celebrates winning Game 7 of the NBA Finals at the American Airlines Arena June 20, 2013 in Miami, Florida. The Miami Heat, led by NBA Most Valuable Player LeBron James, won the NBA Finals for the second consecutive year by defeating the San Antonio Spurs 95-88 in game seven of the championship series. AFP PHOTO / Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

LeBron James (L) and Dwyane Wade (R) of the Miami Heat celebrate winning Game 7 of the NBA Finals over the San Antonio Spurs at the American Airlines Arena June 20, 2013 in Miami, Florida. The Miami Heat, led by NBA Most Valuable Player LeBron James (2nd-L), won the NBA Finals for the second consecutive year by defeating the San Antonio Spurs 95-88 in game seven of the championship series. AFP PHOTO / Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

The Miami Heat and staff celebrate winning Game 7 of the NBA Finals over the San Antonio Spurs at the American Airlines Arena June 20, 2013 in Miami, Florida. The Miami Heat, led by NBA Most Valuable Player LeBron James (2nd-L), won the NBA Finals for the second consecutive year by defeating the San Antonio Spurs 95-88 in game seven of the championship series. AFP PHOTO / Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

The Miami Heat celebrate winning Game 7 of the NBA Finals at the American Airlines Arena June 20, 2013 in Miami, Florida. The Miami Heat, led by NBA Most Valuable Player LeBron James (2nd-L), won the NBA Finals for the second consecutive year by defeating the San Antonio Spurs 95-88 in game seven of the championship series. AFP PHOTO / Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

Dwyane Wade (L), LeBron James (C) and Chris Bosh (R) of the Miami Heat celebrate winning Game 7 of the NBA Finals at the American Airlines Arena June 20, 2013 in Miami, Florida. The Miami Heat, led by NBA Most Valuable Player LeBron James, won the NBA Finals for the second consecutive year by defeating the San Antonio Spurs 95-88 in game seven of the championship series. AFP PHOTO / Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

LeBron James of the Miami Heat celebrates winning Game 7 of the NBA Finals at the American Airlines Arena June 20, 2013 in Miami, Florida. The Miami Heat, led by NBA Most Valuable Player LeBron James, won the NBA Finals for the second consecutive year by defeating the San Antonio Spurs 95-88 in game seven of the championship series. AFP PHOTO / Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

The Miami Heat and staff celebrate winning Game 7 of the NBA Finals over the San Antonio Spurs at the American Airlines Arena June 20, 2013 in Miami, Florida. The Miami Heat, led by NBA Most Valuable Player LeBron James (2nd-L), won the NBA Finals for the second consecutive year by defeating the San Antonio Spurs 95-88 in game seven of the championship series. AFP PHOTO / Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

The Miami Heat and staff celebrate winning Game 7 of the NBA Finals over the San Antonio Spurs at the American Airlines Arena June 20, 2013 in Miami, Florida. The Miami Heat, led by NBA Most Valuable Player LeBron James (2nd-L), won the NBA Finals for the second consecutive year by defeating the San Antonio Spurs 95-88 in game seven of the championship series. AFP PHOTO / Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

Chris Bosh

The Miami Heat's Chris Bosh (1) celebrates after the second half in Game 7 of the NBA basketball championship against the San Antonio Spurs, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship.(AP Photo/Steve Mitchell, Pool)

Miami Heat's Chris Bosh (1) celebrates after winning Game 7 of the NBA basketball championships against the San Antonio Spurs Friday, June 21, 2013, in Miami. The 95-88 win is Miami's second straight NBA championship.(AP Photo/Steve Mitchell, Pool)

Pat Riley, David Fizdale, Erik Spoelstra

From left, Miami Heat president Pat Riley, assistant coach David Fizdale, and head coach Erik Spoelstra celebrate after Game 7 of the NBA basketball championships, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship.(AP Photo/Wilfredo Lee)

Pat Riley,,David Fizdale ,LeBron James

Miami Heat president Pat Riley, left, and Miami Heat assistant coach David Fizdale greet LeBron James (6) after Game 7 of the NBA basketball championship, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Wilfredo Lee)

Pat Riley, David Fizdale, Erik Spoelstra

From left, Miami Heat president Pat Riley, assistant coach David Fizdale, and head coach Erik Spoelstra celebrate after Game 7 of the NBA basketball championships, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship.(AP Photo/Wilfredo Lee)

The Miami Heat's LeBron James holds the the Larry O'Brien NBA Championship Trophy after Game 7 of the NBA basketball championship against the San Antonio Spurs, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Lynne Sladky

LeBron James, Bill Russell

The Miami Heat's LeBron James, left, holding the Larry O'Brien NBA Championship Trophy is given the Bill Russell NBA Finals Most Valuable Player Award, by Former NBA player Bill Russell after Game 7 of the NBA basketball championship against the San Antonio Spurs, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Lynne Sladky

LeBron James, Bill Russell

The Miami Heat's LeBron James, left, holds the Larry O'Brien NBA Championship Trophy and the Bill Russell NBA Finals Most Valuable Player Award, as former NBA player Bill Russell, right looks on after Game 7 of the NBA basketball championship against the San Antonio Spurs, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Lynne Sladky

The Miami Heat celebrate after defeating the San Antonio Spurs 95-88 to win their second straight NBA championship after Game 7 of the NBA basketball championships, Friday, June 21, 2013, in Miami. (AP Photo/Lynne Sladky)

Mario Chalmers, Chris Bosh, Dwyane Wade

From left, Miami Heat players Mario Chalmers, Chris Bosh, and Dwyane Wade celebrate after defeating the San Antonio Spurs 95-88 to win their second straight NBA championship after Game 7 of the NBA basketball championships, Friday, June 21, 2013, in Miami. (AP Photo/Wilfredo Lee)

The Miami Heat's LeBron James, Dwyane Wade and Mike Miller, from left, celebrate after Game 7 of the NBA basketball championship against the San Antonio Spurs, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Wilfredo Lee)

The Miami Heat celebrate after defeating the San Antonio Spurs 95-88 to win their second straight NBA championship after Game 7 of the NBA basketball championships, Friday, June 21, 2013, in Miami. (AP Photo/Lynne Sladky)

Norris Cole

Norris Cole carries the trophy during the after Game 7 of the NBA basketball championships, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Wilfredo Lee)

Miami Heat fans celebrate the Championship after the Heat's win against the San Antonio Spurs after the Game 7 of the NBA final basketball series in Miami on Friday, June 21, 2013.. The Heat beat the San Antonio Spurs 88-95 to win to their second straight title. (AP Photo/Javier Galeano)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

LeBron James of the Miami Heat speaks with reporters after Game 7 of the NBA Finals at the American Airlines Arena June 20, 2013 in Miami, Florida. The Miami Heat beat the San Antonio Spurs 95-88 to become the 2013 NBA champions. AFP PHOTO/Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

LeBron James of the Miami Heat speaks with reporters after Game 7 of the NBA Finals at the American Airlines Arena June 20, 2013 in Miami, Florida. The Miami Heat beat the San Antonio Spurs 95-88 to become the 2013 NBA champions. AFP PHOTO/Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

The Miami Herald headlining the Miami Heat's victory over the San Antonio Spurs is displayed at the American Airlines Arena following Game 7 of the NBA Finals June 20, 2013 in Miami, Florida. The Miami Heat, led by NBA Most Valuable Player LeBron James (2nd-L), won the NBA Finals for the second consecutive year by defeating the San Antonio Spurs 95-88 in game seven of the championship series. AFP PHOTO / Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

Micky Arison

Miami Heat owner Micky Arison speaks to the media after Game 7 of the NBA basketball championship game against the San Antonio Spurs, Friday, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Wilfredo Lee)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

Dwyane Wade of the Miami Heat speaks to reporters after Game 7 of the NBA Finals at the American Airlines Arena June 20, 2013 in Miami, Florida. The Miami Heat beat the San Antonio Spurs 95-88 to win the 2013 NBA Championship. AFP PHOTO/Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

BKN-NBA-FINALS-SPURS-HEAT-GAME 7

Dwyane Wade of the Miami Heat speaks to reporters after Game 7 of the NBA Finals at the American Airlines Arena June 20, 2013 in Miami, Florida. The Miami Heat beat the San Antonio Spurs 95-88 to win the 2013 NBA Championship. AFP PHOTO/Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

San Antonio Spurs v Miami Heat - Game 7

MIAMI, FL - JUNE 20: Shane Battier #31 of the Miami Heat celebrates after defeating the San Antonio Spurs 95-88 to win Game Seven of the 2013 NBA Finals at AmericanAirlines Arena on June 20, 2013 in Miami, Florida. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, User is consenting to the terms and conditions of the Getty Images License Agreement. (Photo by Mike Ehrmann/Getty Images)

San Antonio Spurs v Miami Heat - Game 7

MIAMI, FL - JUNE 20: Dwyane Wade #3 of the Miami Heat hugs teammate Shane Battier #31 after defeating the San Antonio Spurs 95-88 to win Game Seven of the 2013 NBA Finals at AmericanAirlines Arena on June 20, 2013 in Miami, Florida. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and or using this photograph, User is consenting to the terms and conditions of the Getty Images License Agreement. (Photo by Kevin C. Cox/Getty Images)

Pat Riley, , Erik Spoelstra

Miami Heat President Pat Riley, right, and head coach Erik Spoelstra celebrate the team's second NBA championship, Friday morning, June 21, 2013, in Miami. The Miami Heat defeated the San Antonio Spurs 95-88 to win their second straight NBA championship. (AP Photo/Wilfredo Lee)

Source: http://www.huffingtonpost.com/2013/06/21/espn-bill-simmons-the-decision-lebron-heat_n_3476387.html

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Study on fragile newborns challenges current practices

June 20, 2013 ? One of the largest clinical trials done in infants with congenital (present at birth) heart diseases, published in the New England Journal of Medicine, shows that the increasingly common practice of using the drug clopidogrel (Plavix?) to reduce shunt-related blood flow issues is not effective in the dose studied.

"Once again, pediatric-specific research shows that newborns and infants are not little adults," said David Wessel, MD, Chief Medical Officer, Children's National Medical Center, and lead author on the international study published in the June 20, 2013 issue of the New England Journal of Medicine. "The take away message for pediatric cardiac care providers is to reconsider use of Plavix? in certain cases. In pediatric medicine, the assumption is that smaller doses of a drug that works in adults will work in infants, but our study shows that this is not true for these young patients. For the parents of these fragile newborns, it is important to understand that research informs best practices, and they need to be informed advocates for their children."

The objective of this international trial, which included more than 900 patients seen across 134 centers in 33 countries, was to evaluate the efficacy of Plavix? compared with placebo for the reduction of all-cause mortality and shunt-related morbidity in neonates and infants with cyanotic congenital heart disease palliated with systemic-to-pulmonary artery shunts. Many forms of congenital heart disease can be repaired in early infancy, and pulmonary blood flow with shunts is an important consideration during initial treatment that may include reconstructive heart surgery for defects in heart ventricles.

As the authors note, effective prevention for thrombosis (blood clots) in neonates and infants with these heart conditions had not been previously tested, although aspirin treatment was associated with significantly lower risk of mortality and shunt thrombosis in a separate registry developed before this trial. Preventive treatment in adult patients who develop clots in coronary arteries often combines aspirin and Plavix?. As happens with many drugs approved for use in adults, Plavix? use is spreading into pediatric practice without sound evidence, according to study authors. In fact, they continue, use of this drug has increased 15-fold from 2001 to 2009 in children's hospitals in the US.

This study showed no benefit from adding Plavix? to current treatment, which often includes aspirin. As noted in the study, the use of Plavix? to address thrombosis in newborns and infants being palliated with systemic-to-pulmonary artery shunts does not reduce all-cause mortality or shunt-related morbidity.

Further analysis (not part of the original trial design) supports the notion that aspirin alone may be effective at reducing the risk of clot formation in these infants. The study authors point out that the trial suggests that switching from aspirin alone to Plavix? alone at the dose studied is not a good idea.

"This is a good illustration of the successful collaboration between industry and academia to conduct clinical research in children under the written request process of FDA's Best Pharmaceuticals for Children Act (BPCA), noted Edward Connor, MD, MBE, Director of Innovation Development at Children's National and internationally recognized expert on drug development. "Studies of drugs in children are essential to inform child health care providers regarding safety and efficacy in this population. The need for data in newborns is especially important, given known developmental differences in this population compared to adults."

With the enactment of the Pediatric Provisions of the Food and Drug Administration Safety and Innovation Act (FDASIA) in 2012, BPCA and the Pediatric Research Equity Act have become permanent, providing both requirements and incentives for the conduct of clinical trials in children. FDASIA recognizes the value of conducting studies in the neonates and enables FDA to add personnel with expertise in newborns. Incentives to manufacturers include patent extensions if a trial is properly designed, executed, and approved by the FDA.

Worldwide, heart defects are the most common congenital birth defect; tens of thousands of children are born with heart defects each year, and many of these defects can be treated with medications or with procedures, including reconstructive surgery or interventional catheterization.

The Clopidogrel to Lower Arterial Thrombotic Risk in Neonates and Infants Trial (CLARINET) was a double-blinded, randomized, placebo-controlled, parallel group, event driven trial. The study was sponsored by a collaboration between Sanofi-Aventis and Bristol-Myers Squibb.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/mSCSydLf-go/130620142940.htm

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Local sports briefs: Golden Giants top Hutch

KU?S HANNA 1 OFF THE LEAD AT WESTERN JUNIOR: After shooting a course-record 8-under 63 in the first round of the 96th Western Junior at Meridan Hills Country Club in Indianapolis, incoming University of Kansas men?s golf freshman Chase Hanna carded a 2-over 73 Wednesday and sits one stroke off the lead. Competing against 156 of the top-ranked national and international junior golfers ages 15-19, the Leawood native?s 63 include a 6-under 29 on the front nine.

KU ADDS FRENCH SOCCER PLAYER: Kansas women?s soccer announced Wednesday the addition of Aur?lie Gagnet, a standout defender for the U19 French national team.

?I saw Aur?lie playing in the Euro U19 Championships in April and knew right away she was someone I needed to go after to play at Kansas,? said Kansas coach Mark Francis. ?Aur?lie is very quick, attacks very well out of the back and is very good technically.?

FREE STATE?S HARMON-THOMAS EARNS GATORADE PLAYER OF THE YEAR: Free State?s Alexa Harmon-Thomas was named the Gatorade Kansas girls track and field athlete of the year on Wednesday. The 5-foot-11 junior won three individual Class 6A state titles (100-meter hurdles, 300 hurdles and long jump) in May and led the Firebirds to the state championship as a team. She also finished second in the high jump and won the heptathlon at the Great Southwest Classic.

Source: http://cjonline.com/sports/2013-06-19/local-sports-briefs-golden-giants-top-hutch

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Editor's desk: #TM13

Last week was a whirlwind. We're in full on prep mode for #TM13 in New York City and that meant crushing it for endless hours every day. On the plus side, and it's a huge plus side, I got to crush it not only with the likes of Kevin Michaluk, Phil Nickinson, and Daniel Rubino, but with iMore's own Georgia and Peter Cohen, Mobile Nations luminaries like Marcus Adolfsson, Derek Kessler, Alex Dobie, Ashley Esqueda, David Lundblad, and Jose Negron, the always awesome Martin Reisch and -- oh yeah -- Cali Lewis and John P. of GeekBeat.tv as well.

We've been doing a lot of teasing about #TM13 on Twitter, Google+, YouTube, and more, but for anyone who's been on this walk for us for a while, it should be fairly obvious where's we've been and where we're going. Back when we were still Smartphone Experts, we did the Round Robin for 3 years in a row. When Microsoft and BlackBerry got left behind for a while, it made that impossible to continue in a meaningful way. Now that Windows Phone and BlackBerry 10 have launched, everyone is firing on all cylinders again, and that makes things interesting.

We're Mobile Nations now, however, and that means the old Round Robin has to give way to give way to something equally newer, better, and bolder.

Enter #TM13.

I don't want to oversell it. It's going to be a blast, and it's going to benefit all of the Mobile Nations communities in a lot of subtle yet cool ways for a long time to come, but we're not HALO dropping Phil with a pair of glasses on, or shooting Kevin out of a canon in Times Square to see how many characters he can type on a QWERTY before splat-down, or anything stunty like that. Now I did get hung off the roof of a 50 floor building, but the intent here isn't shock and awe. It's what Mobile Nations always does -- entertain, inform, and engage our awesome community.

Speaking of which, Georgia, Martin, and I managed to knock this little video out at the Grand Central Apple Store. They have a rule that you can't use a tripod or monopod, so Martin had to shoot hand-held and we had to stabilize in Final Cut Pro X, which led to some background warp. I like to think it's just rocking out to the iMore theme though. (And by the way, if you haven't subscribed to the iMore YouTube channel yet, do that ASAP -- we've got some great stuff coming your way over the next few weeks...)

I'll be in NYC for another week, but Peter starts full time tomorrow, so look for much more from both of us, and the whole team, as the week goes on.

After that, it's full speed ahead to WWDC 2013 and what I hope is the first look at iOS 7 and OS X 10.9. It's been a long, long, LONG, time since an Apple exec stepped out on the Keynote stage. Any guesses what they have in store for us?

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/IJ1E1f-QdW4/story01.htm

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Anti-abortion movement seeks new laws with Gosnell trial

Anti-abortion protesters at January's March for Life in Washington. (Brendan Hoffman/Getty)

Anti-abortion activists are harnessing the outrage generated over the trial of a Philadelphia abortion doctor to pressure lawmakers to pass more restrictive abortion laws.

The activists say the trial of 72-year-old Kermit Gosnell, which concludes Monday as attorneys on both sides make their closing arguments, shows that late-term abortions are inhumane and unsafe and should be banned.

Gosnell is charged with murder in the deaths of four babies who were born alive after abortion procedures (he is alleged to have cut their spinal cords) and in the death of a woman who died of a drug overdose he allegedly administered.

Gosnell faces other charges, including violating Pennsylvania's law against performing abortions after 24 weeks of pregnancy; violating a state law requiring a 24-hour waiting period for patients before obtaining an abortion; and of endangering child welfare by employing a 15-year-old in the clinic, which investigators labeled a "house of horrors."

Abortion foes say Gosnell's crimes are representative of larger abuses in late-term abortion clinics, while abortion rights advocates say he is a criminal outlier who would not have been stopped by more regulations.

One player in the anti-abortion movement, the Susan B. Anthony List, is lobbying for a bill to ban all abortions performed in Washington, D.C., after 20 weeks of pregnancy. The group has generated thousands of letters to lawmakers in support of the "D.C. Pain-Capable Unborn Child Protection Act," which was introduced by Arizona Republican Rep. Trent Franks. The group is also hoping to convince lawmakers to introduce a national version of the bill.

"What is the difference between killing a baby minutes before delivery compared to moments after? Only the barest of legal nuances," SBA List President Marjorie Dannenfelser said in a statement tying the proposed D.C. law to Gosnell's alleged crimes. ?It is an outrage that in the shadow of the Capitol, children can legally have their lives ended through methods equally brutal to those employed by Gosnell."

The proposed 20-week ban is part of a wave of anti-abortion legislation that is attempting to directly challenge the Supreme Court's 1973 Roe v. Wade ruling, which said the government cannot ban abortions that take place before a fetus can survive outside the womb. (The point of viability is considered to be at about 24 weeks, though that point is debated.)

This year, 10 states have passed or are poised to pass legislation to ban abortions after 20 weeks, according to the Guttmacher Institute, which tracks reproductive health issues. Arkansas and North Dakota went even further, recently banning abortions that occur when a fetal heartbeat can be detected, which can happen as early as six weeks into a pregnancy.

On Friday, President Barack Obama criticized some of those laws in a speech to Planned Parenthood.

?A woman may not even know that she?s pregnant at six weeks,? he said of the North Dakota law.

Those who support abortion rights note that Gosnell was allegedly in violation of dozens of existing laws.

"The important thing to remember is that Kermit Gosnell was running a criminal enterprise, not a health care facility," said Eric Ferrero, a spokesman for Planned Parenthood, the leading reproductive health care provider and a proponent of abortion rights. (Planned Parenthood does not generally perform late-term abortions.)

"He was violating dozens and dozens of laws and regulations that were already on the books. New regulations would not have stopped him," Ferrero said.

Federal law requires health care providers to try to save the lives of babies born alive during abortion procedures. Abortions after 21 weeks make up less than 1 percent of all abortions performed in the U.S. each year; the vast majority of abortions take place during the first trimester.

Others in the anti-abortion movement think the Gosnell case may help their cause to regulate clinics more strictly, as well as win over more supporters in the general public to their cause.

James Bopp Jr., the general counsel for National Right to Life, told Yahoo News that the case gives fuel to the argument that abortion clinics should be more strictly regulated. "When the realities of abortion are exposed to the public, it tends to be a rather gruesome business and people do react to that," Bopp said.

The Gosnell case has already prompted Pennsylvania lawmakers to pass a law that requires clinics to be regulated in the same way that outpatient surgery centers are. That means doors, hallways and elevators in the clinic must fit a stretcher, for example, in case a patient needs to be rushed to a hospital. Texas passed similar legislation.

Ferrero said such regulations tie up legitimate clinics in red tape, and would not have stopped someone like Gosnell?who is accused of flouting a number of federal, state and local laws?from criminal practices. The larger campaign to restrict abortion predates the furor over Gosnell, Ferrero said.

"Extreme activists and politicians will certainly try to use this to try to advance their agenda of making abortion inaccessible and unavailable for women, but that is clearly part of a larger, long term political agenda and political campaign among these folks," Ferrero said.

Meanwhile, the anti-abortion group Live Action, led by activist Lila Rose, released undercover videos Monday showing employees at two late-term abortion clinics explaining what would happen if a baby were born alive during an abortion to women they believed were patients.

One unidentified staff member at a Bronx clinic said babies born alive would be placed in a "solution" that would kill them. (The clinic's manager told the Washington Post a baby had never been born alive during an abortion there and that the staff member was uninformed.) A doctor in Washington, D.C., is seen on the tape saying he would be legally obligated to help a baby born alive, but that it would probably die.

In an interview, Rose said she was not interested so much in convincing politicians to ban late term abortions, but rather to change "hearts and minds."

"I think the most important thing is making sure that every person and particularly women in America know exactly what these procedures are and what they do," she said.

Source: http://news.yahoo.com/blogs/lookout/anti-abortion-movement-seeks-laws-gosnell-trial-201034006.html

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Team of rivals: Italy, finally, forms new government (+video)

Center-left leader Enrico Letta will be Italy's new prime minister, after his party formed a coalition government with former Premier Silvio Berlusconi's conservatives.

By Frances D'Emilio,?Associated Press / April 27, 2013

Italian Premier-designate Enrico Letta speaks at the Quirinale Presidential Palace in Rome, Saturday, April 27, 2013. Italy has finally has a new government, a coalition of Berlusconi's forces and center-left rivals who forged an unusual alliance.

(AP Photo/Domenico Stinellis)

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Center-left leader Enrico Letta forged a new Italian government Saturday in a coalition with former Premier Silvio Berlusconi's conservatives, an unusual alliance of bitter rivals that broke a two-month political stalemate from inconclusive elections in the recession-mired country.

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The daunting achievement was pulled off by Letta, who will be sworn in as premier along with the new Cabinet on Sunday at the presidential Quirinal Palace.

Letta, 46, is a moderate with a reputation as a political bridge-builder. He is also the nephew Berlusconi's longtime adviser, Gianni Letta, a relationship seen as smoothing over often nasty interaction between the two main coalition partners.

Serving as deputy premier and interior minister will be Berlusconi's top political aide, Angelino Alfano. He is a former justice minister who was the architect of legislation that critics say was tailor-made to help media mogul Berlusconi in his many judicial woes.

The creation of the coalition capped the latest political comeback for Berlusconi, a former three-time premier who was forced to resign in 2011 as Italy slid deeper in to the eurozone's sovereign debt crisis.

On Monday, Letta is expected to lay out his strategy to Parliament, ahead of required confidence votes from the Chamber of Deputies and the Senate.

"We negotiated for the formation of the government without throwing up any stop signs," Berlusconi to told one of his TV networks. "That's how we contributed to forming a government in short time" after Letta was tapped Wednesday.

Berlusconi, a fervent anti-Communist, views Italy's left as a personal nemesis, and Letta's Democratic Party has some of its roots in what was the West's largest Communist Party.

Letta expressed "sober satisfaction over the team we put together and its willingness" to form a coalition.

Only a few weeks earlier, the head of the Democrats, Pier Luigi Bersani, resigned from the party post in humiliation and he refused Berlusconi's offer for a "grand coalition" and futilely tried to form a government without the center-right. Letta was a Bersani loyalist.

Bersani hailed the coalition formula as a "necessary compromise" that gives the country "freshness and solidarity."

The No. 3 bloc in Parliament, the anti-establishment 5 Star Movement, is led by comic Beppe Grillo, who ruled out any alliance with the largely sullied political class that has ruled Italy for decades.

President Giorgio Napolitano, who tasked Letta with creating a government out of bitter rivals, called upon the coalition partners to work "in a spirit of absolute, indispensable cohesion" as they work for sorely needed political and economic reforms.

The 87-year-old head of state sounded almost breathless as he expressed confidence the rivals could work together "without conflict or prejudices to find the right solutions" to the country's pressing economic and political problems.

Napolitano didn't name the challenges, but they include fighting unemployment, especially for young people, and corruption sullying much of the political class.

Napolitano said: "It was and is the only possible government," and one "whose formation couldn't be delayed further, in the interest of our country and of Europe."

He reluctantly agreed to be re-elected by Parliament earlier this month for another seven-year term because of the political instability.

Italy's economy is No. 3 among eurozone members, and financial markets have been anxiously watching to see if an effective government could be formed to carry on with outgoing Premier Mario Monti's efforts to keep the country from sliding into the eurozone's sovereign debt crisis.

Some Italian political observers have predicted such a hybrid government might last only a few months of Parliament's five-year term, before collapsing in squabbling.

But the fear of elections, especially after the lightning-quick rise of comic Grillo's grassroots movement, could prove to be strong glue.

Giovanni Orsina, deputy director of LUISS university's school of government in Rome, ventured that Letta's new coalition could "last more than we expect, 18 to 24 months, more or less."

The history professor cited "lack of alternatives, and because I believe Parliament's members are not particularly eager to get back to the polling booth and face new elections."

Voters, fed up with new and higher taxes, including a despised property tax revived by Monti, rejected his severe austerity policies.

The small centrist party created in time for the election by Monti, an economist and former European Union commissioner, will participate in the coalition, although Monti won't be in the Cabinet, which is heavy on two novelties ? a large presence of female ministers and Italy's first black minister.

A native of Congo, Cecile Kyenge is a doctor who will serve as minister of integration. Proposals to make it easier for Italy' growing immigrant population to become citizens have gone nowhere in Parliament amid fierce opposition from the anti-immigrant Northern League party. The party, a Berlusconi ally, isn't in the new government.

Prominent among the women in the Cabinet is Emma Bonino, a former EU commissioner and Radical Party leader who will serve as foreign minister. Olympic gold medal kayaker Josefa Idem was tapped as minister of equal opportunity and sports.

Letta comes from a moderate wing of the left-rooted Democratic Party that is close to the Vatican. Since Parliament always includes an array of lawmakers enjoying good ties to the politically influential Catholic church in Italy, this was one more qualification on Letta's bridge-building resume.

The father of three sons, he lives in Rome's working-class Testaccio neighborhood. When he was tapped by Napolitano on Wednesday, he drove his own car to the Quirinal Palace, in what was seen as a photo opportunity gesture to Italian taxpayers who widely despise the huge fleet of luxury cars that shuttles around ministers and lawmakers.

In 1998, when he was 32, Letta became the youngest minister in Italy's history when he served as minister for European policy for then-Premier Massimo D'Alema, an ex-Communist leader. Letta seemed a natural for that post. He spent his childhood in Strasbourg, home to the European Parliament, and studied international law before jumping into politics.

Copyright 2013 The Associated Press.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/WJ77Gys4ack/Team-of-rivals-Italy-finally-forms-new-government-video

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Researchers engineer 'protein switch' to dissect role of cancer's key players

Apr. 10, 2013 ? Researchers at the University of North Carolina at Chapel Hill School of Medicine have "rationally rewired" some of the cell's smallest components to create proteins that can be switched on or off by command. These "protein switches" can be used to interrogate the inner workings of each cell, helping scientists uncover the molecular mechanisms of human health and disease.

In the first application of this approach, the UNC researchers showed how a protein called Src kinase influences the way cells extend and move, a previously unknown role that is consistent with the protein's ties to tumor progression and metastasis.

"This rationally designed control of protein conformations represents a breakthrough in computational protein design," said senior study author Nikolay Dokholyan, PhD, a professor of biochemistry and biophysics. "We now have a new tool for delineating the activities of various proteins in living cells in a way that was never before possible."

The research was published online ahead of print in the Proceedings of the National Academy of Sciences. In the study, Dokholyan created a "switch" that would make a protein wobbly and unable to do its job unless it was flipped "on" by a drug called rapamycin, which would stabilize the protein and let it perform its function.

The approach is a simpler and more reliable version of a protein engineering system pioneered three years ago by Dokholyan and Klaus Hahn, professor of pharmacology at UNC, called rapamycin regulated or RapR. In the old approach, the switching mechanism depended on two proteins and the drug. The first protein -- the one the researchers wanted to study -- was given the RapR modification and put in cells in tissue culture. The second protein was placed in the cells as well, but simply floated around until the addition of drug caused it to latch on to the modification in the first protein and turn it on. The problem with the approach was that some cells would have a lot of the first protein and less of the second, or vice versa.

"It became the Achilles heel of the technique, because there was variability in the results due to the different ratios between the proteins," said Hahn. "What Dokholyan was able to do, which was extremely challenging from a protein engineering standpoint, was to combine the two parts into one."

Dokholyan and his colleagues took the two proteins and broke them apart into their individual components, structures called alpha helices and beta sheets. They then rewired them together to make a whole new protein where the parts could interact with each other. When researchers compared this system, called uniRapR, with the previous approach, they found the new one gave cleaner, more reliable and more consistent results.

They then applied the technique to study Src kinase, a protein involved in the metastasis or spread of tumor cells. Scientists had postulated that Src kinase plays a role in cell motility, but previous methods have not allowed them to isolate its activity from other similar proteins.

Working both in cultured human cells and in the model organism zebrafish, the researchers showed that turning on Src causes the cell to extend its edges as part of cell movement. Now that they have dissected the role of one protein, the researchers plan to look at a variety of other kinases to understand their roles in the development, progression, and spread of cancer.

The research was funded in by the National Institutes of Health, the National Institute of Environmental Health Sciences, and the National Cancer Institute. Study co-authors from UNC were Onur Dagliyan; David Shirvanyants, PhD; Andrei V. Karginov, PhD; Feng Deng, PhD; Lanette Fee; and Srinivas N. Chandrasekaran. Co-authors from the University of Wisconsin, Madison, were Christina M. Freisinger, Gromoslaw A. Smolen, and Anna Huttenlocher.

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Story Source:

The above story is reprinted from materials provided by University of North Carolina School of Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. O. Dagliyan, D. Shirvanyants, A. V. Karginov, F. Ding, L. Fee, S. N. Chandrasekaran, C. M. Freisinger, G. A. Smolen, A. Huttenlocher, K. M. Hahn, N. V. Dokholyan. Rational design of a ligand-controlled protein conformational switch. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1218319110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/SzapJq_n8R4/130410154906.htm

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